A novel approach to measure local cerebral haematocrit using MRI.

ABSTRACT: The percentage blood volume occupied by red blood cells is known as haematocrit. While it is straightforward to measure haematocrit in large arteries, it is very challenging to do it in microvasculature (cerebral haematocrit). Currently, this can only be done using invasive methods (e.g. PET), but their use is very limited. Local variations in cerebral haematocrit have been reported in various brain abnormalities (e.g. stroke, tumours). We propose a new approach to image cerebral haematocrit using MRI, which relies on combining data from two measurements: one that provideshaematocrit-weightedand other onehaematocrit-independentvalues of the same parameter, thus providing an easily obtainable measurement of this important physiological parameter. Four different implementations are described

SUBMITTER: Calamante F 

PROVIDER: S-EPMC4821017 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature