Genetic analysis for a shared biological basis between migraine and coronary artery disease.

ABSTRACT:

Objective

To apply genetic analysis of genome-wide association data to study the extent and nature of a shared biological basis between migraine and coronary artery disease (CAD).

Methods

Four separate methods for cross-phenotype genetic analysis were applied on data from 2 large-scale genome-wide association studies of migraine (19,981 cases, 56,667 controls) and CAD (21,076 cases, 63,014 controls). The first 2 methods quantified the extent of overlapping risk variants and assessed the load of CAD risk loci in migraineurs. Genomic regions of shared risk were then identified by analysis of covariance patterns between the 2 phenotypes and by querying known genome-wide significant loci.

Results

We found a significant overlap of genetic risk loci for migraine and CAD. Wh

SUBMITTER: Winsvold BS 

PROVIDER: S-EPMC4821079 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature