Early afterdepolarizations promote transmural reentry in ischemic human ventricles with reduced repolarization reserve.

ABSTRACT:

Aims

Acute ischemia is a major cause of sudden arrhythmic death, further promoted by potassium current blockers. Macro-reentry around the ischemic region and early afterdepolarizations (EADs) caused by electrotonic current have been suggested as potential mechanisms in animal and isolated cell studies. However, ventricular and human-specific arrhythmia mechanisms and their modulation by repolarization reserve remain unclear. The goal of this paper is to unravel multiscale mechanisms underlying the modulation of arrhythmic risk by potassium current (IKr) block in human ventricles with acute regional ischemia.

Methods and results

A human ventricular biophysically-detailed model, with acute regional ischemia is constructed by integrating experimental knowledge on the electrophy

SUBMITTER: Dutta S 

PROVIDER: S-EPMC4821233 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature