Evolutionary diversification of retinoic acid receptor ligand-binding pocket structure by molecular tinkering.

ABSTRACT: Whole genome duplications (WGDs) have been classically associated with the origin of evolutionary novelties and the so-called duplication-degeneration-complementation model describes the possible fates of genes after duplication. However, how sequence divergence effectively allows functional changes between gene duplicates is still unclear. In the vertebrate lineage, two rounds of WGDs took place, giving rise to paralogous gene copies observed for many gene families. For the retinoic acid receptors (RARs), for example, which are members of the nuclear hormone receptor (NR) superfamily, a unique ancestral gene has been duplicated resulting in three vertebrate paralogues: RARα, RARβ and RARγ. It has previously been shown that this single ancestral RAR was neofunctionalized to give rise to a

SUBMITTER: Gutierrez-Mazariegos J 

PROVIDER: S-EPMC4821253 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature