Cytokine responses in birds challenged with the human food-borne pathogen Campylobacter jejuni implies a Th17 response.

ABSTRACT: Development of process orientated understanding of cytokine interactions within the gastrointestinal tract during an immune response to pathogens requires experimentation and statistical modelling. The immune response against pathogen challenge depends on the specific threat to the host. Here, we show that broiler chickens mount a breed-dependent immune response to Campylobacter jejuni infection in the caeca by analysing experimental data using frequentist and Bayesian structural equation models (SEM). SEM provides a framework by which cytokine interdependencies, based on prior knowledge, can be tested. In both breeds important cytokines including pro-inflammatory interleukin (IL)-1β, , IL-4, IL-17A, interferon (IFN)-γ and anti-inflammatory IL-10 and transforming growth factor (TGF)-β4 wer

SUBMITTER: Reid WD 

PROVIDER: S-EPMC4821255 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature