Association of a NOS3 gene polymorphism with Behcet's disease but not with Vogt-Koyanagi-Harada syndrome in Han Chinese.

ABSTRACT:

Purpose

Previous studies have identified that nitric oxide synthase (NOS) genes are associated with several immune-mediated diseases. This study aimed to investigate whether NOS2 and NOS3 gene polymorphisms are associated with Behçet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome in a Han Chinese population.

Methods

An association analysis of NOS2/rs4795067, NOS3/rs1799983 and NOS3/rs1800779 was performed in 733 patients with BD, 800 patients with VKH syndrome, and 1,359 controls using PCR restriction fragment length polymorphism (PCR-RFLP) assay. Statistical analysis was performed with the chi-square test followed by the Bonferroni correction.

Results

The result showed a decreased frequency of the NOS3/rs1799983 GG genotype and an increased frequency of NOS3/

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC4821341 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature