Quantification of Treatment Effect Modification on Both an Additive and Multiplicative Scale.

ABSTRACT:

Background

In both observational and randomized studies, associations with overall survival are by and large assessed on a multiplicative scale using the Cox model. However, clinicians and clinical researchers have an ardent interest in assessing absolute benefit associated with treatments. In older patients, some studies have reported lower relative treatment effect, which might translate into similar or even greater absolute treatment effect given their high baseline hazard for clinical events.

Methods

The effect of treatment and the effect modification of treatment were respectively assessed using a multiplicative and an additive hazard model in an analysis adjusted for propensity score in the context of coronary surgery.

Results

The multiplicative model yielded a

SUBMITTER: Girerd N 

PROVIDER: S-EPMC4821587 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature