Systemic and Pulmonary Vascular Remodelling in Chronic Obstructive Pulmonary Disease.

ABSTRACT:

Background

Chronic Obstructive Pulmonary Disease (COPD) is associated with subclinical systemic atherosclerosis and pulmonary vascular remodelling characterized by intimal hyperplasia and luminal narrowing. We aimed to determine differences in the intimal thickening of systemic and pulmonary arteries in COPD subjects and smokers. Secondary aims include comparisons with a non-smokers group; determining the clinical variables associated with systemic and pulmonary intimal thickening, and the correlations between systemic and pulmonary remodelling changes.

Methods

All consecutive subjects undergoing lung resection were included and divided into 3 groups: 1) COPD, 2) smokers, and 3) non-smokers. Sections of the 5th intercostal artery and muscular pulmonary arteries were measured

SUBMITTER: Munoz-Esquerre M 

PROVIDER: S-EPMC4821623 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature