Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial.

ABSTRACT:

Context

Despite reported success, surgery for pharmacoresistant seizures is often seen as a last resort. Patients are typically referred for surgery after 20 years of seizures, often too late to avoid significant disability and premature death.

Objective

We sought to determine whether surgery soon after failure of 2 antiepileptic drug (AED) trials is superior to continued medical management in controlling seizures and improving quality of life (QOL).

Design, setting, and participants

The Early Randomized Surgical Epilepsy Trial (ERSET) is a multicenter, controlled, parallel-group clinical trial performed at 16 US epilepsy surgery centers. The 38 participants (18 men and 20 women; aged ≥12 years) had mesial temporal lobe epilepsy (MTLE) and disabling seizues for no mor

SUBMITTER: Engel J 

PROVIDER: S-EPMC4821633 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature