HSF-1 activates the ubiquitin proteasome system to promote non-apoptotic developmental cell death in C. elegans.

ABSTRACT: Apoptosis is a prominent metazoan cell death form. Yet, mutations in apoptosis regulators cause only minor defects in vertebrate development, suggesting that another developmental cell death mechanism exists. While some non-apoptotic programs have been molecularly characterized, none appear to control developmental cell culling. Linker-cell-type death (LCD) is a morphologically conserved non-apoptotic cell death process operating in Caenorhabditis elegans and vertebrate development, and is therefore a compelling candidate process complementing apoptosis. However, the details of LCD execution are not known. Here we delineate a molecular-genetic pathway governing LCD in C. elegans. Redundant activities of antagonistic Wnt signals, a temporal control pathway, and mitogen-activated protein kin

SUBMITTER: Kinet MJ 

PROVIDER: S-EPMC4821803 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature