Ontology highlight
ABSTRACT:
SUBMITTER: Gandin V
PROVIDER: S-EPMC4822005 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Nature communications 20160404
Ternary complex (TC) and eIF4F complex assembly are the two major rate-limiting steps in translation initiation regulated by eIF2α phosphorylation and the mTOR/4E-BP pathway, respectively. How TC and eIF4F assembly are coordinated, however, remains largely unknown. We show that mTOR suppresses translation of mRNAs activated under short-term stress wherein TC recycling is attenuated by eIF2α phosphorylation. During acute nutrient or growth factor stimulation, mTORC1 induces eIF2β phosphorylation ...[more]