Vancomycin-sensitive bacteria trigger development of colitis-associated colon cancer by attracting neutrophils.

ABSTRACT: Inflammatory bowel disease confers an increased risk of developing colitis-associated colon cancer (CAC). During the active colitis or developing tumor stage, commensal bacteria show dynamic translocation. However, whether alteration of the bacterial composition in the gut causes CAC is still unclear. To clarify the effect of commensal bacteria on CAC development, we employed an azoxymethane (AOM) and dextran sodium sulfate (DSS)-induced murine CAC model treated with or without antibiotics. In addition, we analyzed the effects of antibiotics on infiltration of myeloid cells, colonic inflammatory responses, and colorectal cancer formation. We found that vancomycin treatment dramatically suppressed tumor development. In addition, AOM/DSS treatment greatly induced the infiltration of Gr-1(hig

SUBMITTER: Tanaka Y 

PROVIDER: S-EPMC4822119 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature