Reversion of AHRR Demethylation Is a Quantitative Biomarker of Smoking Cessation.

ABSTRACT: Smoking is the largest preventable cause of morbidity and mortality in the world. Although there are effective pharmacologic and behavioral treatments for smoking cessation, our inability to objectively quantify smokers' progress in decreasing smoking has been a barrier to both clinical and research efforts. In prior work, we and others have shown that DNA methylation at cg05575921, a CpG residue in the aryl hydrocarbon receptor repressor (AHRR), can be used to determine smoking status and infer cigarette consumption history. In this study, we serially assessed self-report and existing objective markers of cigarette consumption in 35 subjects undergoing smoking cessation therapy, then quantified DNA methylation at cg05575921 at study entry and three subsequent time points. Five subjects wh

SUBMITTER: Philibert R 

PROVIDER: S-EPMC4822186 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature