Fabrication of anatomically-shaped cartilage constructs using decellularized cartilage-derived matrix scaffolds.

ABSTRACT: The native extracellular matrix of cartilage contains entrapped growth factors as well as tissue-specific epitopes for cell-matrix interactions, which make it a potentially attractive biomaterial for cartilage tissue engineering. A limitation to this approach is that the native cartilage extracellular matrix possesses a pore size of only a few nanometers, which inhibits cellular infiltration. Efforts to increase the pore size of cartilage-derived matrix (CDM) scaffolds dramatically attenuate their mechanical properties, which makes them susceptible to cell-mediated contraction. In previous studies, we have demonstrated that collagen crosslinking techniques are capable of preventing cell-mediated contraction in CDM disks. In the current study, we investigated the effects of CDM concentratio

SUBMITTER: Rowland CR 

PROVIDER: S-EPMC4822340 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature