Globally conditioned Granger causality in brain-brain and brain-heart interactions: a combined heart rate variability/ultra-high-field (7 T) functional magnetic resonance imaging study.

ABSTRACT: The causal, directed interactions between brain regions at rest (brain-brain networks) and between resting-state brain activity and autonomic nervous system (ANS) outflow (brain-heart links) have not been completely elucidated. We collected 7 T resting-state functional magnetic resonance imaging (fMRI) data with simultaneous respiration and heartbeat recordings in nine healthy volunteers to investigate (i) the causal interactions between cortical and subcortical brain regions at rest and (ii) the causal interactions between resting-state brain activity and the ANS as quantified through a probabilistic, point-process-based heartbeat model which generates dynamical estimates for sympathetic and parasympathetic activity as well as sympathovagal balance. Given the high amount of information sh

SUBMITTER: Duggento A 

PROVIDER: S-EPMC4822445 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature