Estimate of the impact of FDG-avidity on the dose required for head and neck radiotherapy local control.

ABSTRACT:

Background and purpose

Although FDG-avid tumors are recognized as a potential target for dose escalation, there is no clear basis for selecting a boost dose to counter this apparent radioresistance. Using a novel analysis method, based on the new concept of an outcome-equivalent dose, we estimate the extra dose required to equalize local control between FDG-avid and non-avid head and neck tumors.

Materials and methods

Based on a literature review, five reports of head and neck cancer (423 patients in total), along with an internal validation dataset from our institution (135 oropharynx patients), were used in this analysis. To compensate for the heterogeneity among multi-institutional patient cohorts and corresponding treatment techniques, local control data of the cohorts w

SUBMITTER: Jeong J 

PROVIDER: S-EPMC4822492 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature