Genetic Influences on Plasma Homocysteine Levels in African Americans and Yoruba Nigerians.

ABSTRACT: Plasma homocysteine, a metabolite involved in key cellular methylation processes seems to be implicated in cognitive functions and cardiovascular health with its high levels representing a potential modifiable risk factor for Alzheimer's disease (AD) and other dementias. A better understanding of the genetic factors regulating homocysteine levels, particularly in non-white populations, may help in risk stratification analyses of existing clinical trials and may point to novel targets for homocysteine-lowering therapy. To identify genetic influences on plasma homocysteine levels in individuals with African ancestry, we performed a targeted gene and pathway-based analysis using a priori biological information and then to identify new association performed a genome-wide association study. All

SUBMITTER: Kim S 

PROVIDER: S-EPMC4822513 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature