Serum lipids, lipoproteins, and risk of breast cancer: a nested case-control study using multiple time points.

ABSTRACT:

Background

There is strong evidence that breast cancer risk is influenced by environmental factors. Blood lipid and lipoprotein levels are also influenced by environmental factors and are associated with some breast cancer risk factors. We examined whether serial measures of serum lipids and lipoproteins were associated with breast cancer risk.

Methods

We carried out a nested case-control study within a randomized long-term dietary intervention trial with 4690 women with extensive mammographic density followed for an average of 10 years for breast cancer incidence. We measured lipids in an average of 4.2 blood samples for 279 invasive breast cancer case subjects and 558 matched control subjects. We calculated subaverages of lipids for each subject based on menopausal status

SUBMITTER: Martin LJ 

PROVIDER: S-EPMC4822522 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature