Combined, Independent Small Molecule Release and Shape Memory via Nanogel-Coated Thiourethane Polymer Networks.

ABSTRACT: Drug releasing shape memory polymers (SMPs) were prepared from poly(thiourethane) networks that were coated with drug loaded nanogels through a UV initiated, surface mediated crosslinking reaction. Multifunctional thiol and isocyanate monomers were crosslinked through a step-growth mechanism to produce polymers with a homogeneous network structure that exhibited a sharp glass transition with 97% strain recovery and 96% shape fixity. Incorporating a small stoichiometric excess of thiol groups left pendant functionality for a surface coating reaction. Nanogels with diameter of approximately 10 nm bearing allyl and methacrylate groups were prepared separately via solution free radical polymerization. Coatings with thickness of 10-30 μm were formed via dip-coating and subsequent UV-initiated t

SUBMITTER: Dailing EA 

PROVIDER: S-EPMC4822555 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature