External Validation of the Kidney Failure Risk Equation and Re-Calibration with Addition of Ultrasound Parameters.

ABSTRACT:

Background and objectives

Progression of CKD toward ESRD is heterogeneous. The Kidney Failure Risk Equation (KFRE) was developed to identify CKD patients at high risk of ESRD. We aimed to externally validate KFRE and to test whether the addition of predefined Duplex ultrasound markers - renal resistive index (RRI) or difference of resistive indices in spleen and kidney (DI-RISK) - improved ESRD prediction.

Design, setting, participants, & measurements

The prospective Cardiovascular and Renal Outcome in CKD 2-4 Patients-The Fourth Homburg evaluation (CARE FOR HOMe) study recruits CKD stage G2-G4 patients referred to a tertiary referral center for nephrologic care. Four hundred three CARE FOR HOMe participants enrolled between 2008 and 2012 had available RRI measurements at st

SUBMITTER: Lennartz CS 

PROVIDER: S-EPMC4822670 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature