Modification of Antigen Impacts on Memory Quality after Adenovirus Vaccination.

ABSTRACT: The establishment of robust T cell memory is critical for the development of novel vaccines for infections and cancers. Classical memory generated by CD8(+)T cells is characterized by contracted populations homing to lymphoid organs. T cell memory inflation, as seen for example after CMV infection, is the maintenance of expanded, functional, tissue-associated effector memory cell pools. Such memory pools may also be induced after adenovirus vaccination, and we recently defined common transcriptional and phenotypic features of these populations in mice and humans. However, the rules that govern which epitopes drive memory inflation compared with classical memory are not fully defined, and thus it is not currently possible to direct this process. We used our adenoviral model of memory inflat

SUBMITTER: Colston JM 

PROVIDER: S-EPMC4822682 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature