Alternariol 9-methyl ether from the endophytic fungus Alternaria sp. Samif01 and its bioactivities.

ABSTRACT: One bioactive compound, identified as alternariol 9-methyl ether, was isolated from the crude extract of the endophytic fungus Alternaria sp. Samif01 residing in the roots of Salvia miltiorrhiza Bunge. Alternariol 9-methyl ether was active against bacteria with minimum inhibitory concentration values ranging from 25 to 75?g/mL and median inhibitory concentration (IC50) values ranging from 16.00 to 38.27?g/mL. The IC50 value of alternariol 9-methyl ether against spore germination of Magnaporthe oryzae was 87.18?g/mL. Alternariol 9-methyl ether also showed antinematodal activity against Bursaphelenchus xylophilus and Caenorhabditis elegans with IC50 values of 98.17?g/mL and 74.62?g/mL, respectively. This work is the first report on alternariol 9-methyl ether and its biological activities from the endophytic fungus Alternaria sp. Samif01 derived from S. miltiorrhiza Bunge. The results indicate the potential of Alternaria sp. Samif01 as a source of alternariol 9-methyl ether and also support that alternariol 9-methyl ether is a natural compound with high potential bioactivity against microorganisms.

SUBMITTER: Lou J 

PROVIDER: S-EPMC4822747 | biostudies-literature | 2016 Jan-Mar

REPOSITORIES: biostudies-literature