Should Studies of Diabetes Treatment Stratification Correct for Baseline HbA1c?

ABSTRACT:

Aims

Baseline HbA1c is a major predictor of response to glucose lowering therapy and therefore a potential confounder in studies aiming to identify other predictors. However, baseline adjustment may introduce error if the association between baseline HbA1c and response is substantially due to measurement error and regression to the mean. We aimed to determine whether studies of predictors of response should adjust for baseline HbA1c.

Methods

We assessed the relationship between baseline HbA1c and glycaemic response in 257 participants treated with GLP-1R agonists and assessed whether it reflected measurement error and regression to the mean using duplicate 'pre-baseline' HbA1c measurements not included in the response variable. In this cohort and an additional 2659 participa

SUBMITTER: Jones AG 

PROVIDER: S-EPMC4822872 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature