Predicting Survival from Telomere Length versus Conventional Predictors: A Multinational Population-Based Cohort Study.

ABSTRACT: Telomere length has generated substantial interest as a potential predictor of aging-related diseases and mortality. Some studies have reported significant associations, but few have tested its ability to discriminate between decedents and survivors compared with a broad range of well-established predictors that include both biomarkers and commonly collected self-reported data. Our aim here was to quantify the prognostic value of leukocyte telomere length relative to age, sex, and 19 other variables for predicting five-year mortality among older persons in three countries. We used data from nationally representative surveys in Costa Rica (N = 923, aged 61+), Taiwan (N = 976, aged 54+), and the U.S. (N = 2672, aged 60+). Our study used a prospective cohort design with all-cause mortality du

SUBMITTER: Glei DA 

PROVIDER: S-EPMC4822878 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature