Identification of Differentially Expressed Genes through Integrated Study of Alzheimer's Disease Affected Brain Regions.

ABSTRACT:

Background

Alzheimer's disease (AD) is the most common form of dementia in older adults that damages the brain and results in impaired memory, thinking and behaviour. The identification of differentially expressed genes and related pathways among affected brain regions can provide more information on the mechanisms of AD. In the past decade, several studies have reported many genes that are associated with AD. This wealth of information has become difficult to follow and interpret as most of the results are conflicting. In that case, it is worth doing an integrated study of multiple datasets that helps to increase the total number of samples and the statistical power in detecting biomarkers. In this study, we present an integrated analysis of five different brain region datasets an

SUBMITTER: Puthiyedth N 

PROVIDER: S-EPMC4822961 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature