GATA4 regulates epithelial cell proliferation to control intestinal growth and development in mice.

ABSTRACT:

Background & aims

The embryonic small intestinal epithelium is highly proliferative, and although much is known about mechanisms regulating proliferation in the adult intestine, the mechanisms controlling epithelial cell proliferation in the developing intestine are less clear. GATA4, a transcription factor that regulates proliferation in other developing tissues, is first expressed early in the developing gut in midgut endoderm. GATA4 function within midgut endoderm and the early intestinal epithelium has not been investigated.

Methods

Using Sonic Hedgehog Cre to eliminate GATA4 in the midgut endoderm of mouse embryos, we determined the impact of loss of GATA4 on intestinal development, including epithelial cell proliferation, between E9.5-E18.5.

Results

We found tha

SUBMITTER: Kohlnhofer BM 

PROVIDER: S-EPMC4823006 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature