Ca_v 1.3 (CACNA1D) L-type Ca²⁺ channel dysfunction in CNS disorders.

ABSTRACT: Ca_v 1.3 belongs to the family of voltage-gated L-type Ca²⁺ channels and is encoded by the CACNA1D gene. Ca_v 1.3 channels are not only essential for cardiac pacemaking, hearing and hormone secretion but are also expressed postsynaptically in neurons, where they shape neuronal firing and plasticity. Recent findings provide evidence that human mutations in the CACNA1D gene can confer risk for the development of neuropsychiatric disease and perhaps also epilepsy. Loss of Ca_v 1.3 function, as shown in knock-out mouse models and by human mutations, does not result in neuropsychiatric or neurological disease symptoms, whereas their acute selective pharmacological activation results in a depressive-like behaviour in mice. Therefore it is likely that CACN

SUBMITTER: Pinggera A 

PROVIDER: S-EPMC4823145 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature