Structure of RagB, a major immunodominant outer-membrane surface receptor antigen of Porphyromonas gingivalis.

ABSTRACT: Porphyromonas gingivalis is the main causative agent of periodontitis. It deregulates the inflammatory and innate host immune responses through virulence factors, which include the immunodominant outer-membrane surface receptor antigens A (PgRagA) and B (PgRagB), co-transcribed from the rag pathogenicity island. The former is predicted to be a Ton-dependent porin-type translocator but the targets of this translocation and the molecular function of PgRagB are unknown. Phenomenologically, PgRagB has been linked with epithelial cell invasion and virulence according to murine models. It also acts as a Toll-like receptor agonist and promotes multiple mediators of inflammation. Hence, PgRagB is a candidate for the development of a periodontitis vaccine, which would be facilitated by the knowledg

SUBMITTER: Goulas T 

PROVIDER: S-EPMC4823178 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature