Transplant Tolerance Induction in Newborn Infants: Mechanisms, Advantages, and Potential Strategies.

ABSTRACT: Although several tolerance induction protocols have been successfully implemented in adult renal transplantation, no tolerance induction approach has, as yet, been defined for solid organ transplantations in young infants. Pediatric transplant recipients have a pressing demand for the elaboration of tolerance induction regimens. Indeed, since they display a longer survival time, they are exposed to a higher level of risks linked to long-term immunosuppression (IS) and to chronic rejection. Interestingly, central tolerance induction may be of great interest in newborns, because of their immunological immaturity and the important role of the thymus at this early stage in life. The present review aims to clarify mechanisms and strategies of tolerance induction in these immunologically prematu

SUBMITTER: Pan H 

PROVIDER: S-EPMC4823304 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature