Microbiota-based model improves the sensitivity of fecal immunochemical test for detecting colonic lesions.

ABSTRACT:

Background

Colorectal cancer (CRC) is the second leading cause of death among cancers in the United States. Although individuals diagnosed early have a greater than 90% chance of survival, more than one-third of individuals do not adhere to screening recommendations partly because the standard diagnostics, colonoscopy and sigmoidoscopy, are expensive and invasive. Thus, there is a great need to improve the sensitivity of non-invasive tests to detect early stage cancers and adenomas. Numerous studies have identified shifts in the composition of the gut microbiota associated with the progression of CRC, suggesting that the gut microbiota may represent a reservoir of biomarkers that would complement existing non-invasive methods such as the widely used fecal immunochemical test (FIT).

SUBMITTER: Baxter NT 

PROVIDER: S-EPMC4823848 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature