Knockout of Atg5 delays the maturation and reduces the survival of adult-generated neurons in the hippocampus.

ABSTRACT: Autophagy is an evolutionarily conserved lysosomal degradation pathway that plays important roles in cell maintenance, expansion and differentiation. Removal of genes essential for autophagy from embryonic neural stem and precursor cells reduces the survival and inhibits neuronal differentiation of adult-generated neurons. No study has modified autophagy within the adult precursor cells, leaving the cell-autonomous role of autophagy in adult neurogenesis unknown. Here we demonstrate that autophagic flux exists in the adult dividing progenitor cells and their progeny in the dentate gyrus. To investigate the role of autophagy in adult hippocampal neurogenesis, we genetically deleted Autophagy-related gene 5 (Atg5) that reduced autophagic flux and the survival of the progeny of dividing proge

SUBMITTER: Xi Y 

PROVIDER: S-EPMC4823925 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature