Leveraging Optogenetic-Based Neurovascular Circuit Characterization for Repair.

ABSTRACT: Optogenetic techniques are a powerful tool for determining the role of individual functional components within complex neural circuits. By genetically targeting specific cell types, neural mechanisms can be actively manipulated to gain a better understanding of their origin and function, both in health and disease. The potential of optogenetics is not limited to answering biological questions, as it is also a promising therapeutic approach for neurological diseases. An important prerequisite for this approach is to have an identified target with a uniquely defined role within a given neural circuit. Here, we examine the retinal neurovascular unit, a circuit that incorporates neurons and vascular cells to control blood flow in the retina. We highlight the role of a specific cell type, the c

SUBMITTER: Ivanova E 

PROVIDER: S-EPMC4824015 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature