Development of an endoluminal intestinal lengthening device using a geometric intestinal attachment approach.

ABSTRACT:

Background

Distraction enterogenesis may provide a novel therapy for short bowel syndrome. Previously described methods have relied on isolated intestinal segments or transmural fixation because of ineffective endoluminal attachment. We hypothesized that a novel approach of geometric coupling between a tapering device and the mesenteric curvature would allow trans-stomal distraction enterogenesis.

Methods

A catheter device was designed with tapering stiffness, consisting of a stiff catheter with a taper to a flexible latex tip to prevent perforation. Yorkshire pigs underwent creation of a jejunal Roux limb with device placed via jejunostomy. Intestinal attachment was achieved without a substantial decrease in bowel perfusion as measured by laser Doppler. An external clamp wa

SUBMITTER: Demehri FR 

PROVIDER: S-EPMC4824058 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature