Age effects and sex differences in human brain white matter of young to middle-aged adults: A DTI, NODDI, and q-space study.

ABSTRACT: Microstructural changes in human brain white matter of young to middle-aged adults were studied using advanced diffusion Magnetic Resonance Imaging (dMRI). Multiple shell diffusion-weighted data were acquired using the Hybrid Diffusion Imaging (HYDI). The HYDI method is extremely versatile and data were analyzed using Diffusion Tensor Imaging (DTI), Neurite Orientation Dispersion and Density Imaging (NODDI), and q-space imaging approaches. Twenty-four females and 23 males between 18 and 55years of age were included in this study. The impact of age and sex on diffusion metrics were tested using least squares linear regressions in 48 white matter regions of interest (ROIs) across the whole brain and adjusted for multiple comparisons across ROIs. In this study, white matter projections to eit

SUBMITTER: Kodiweera C 

PROVIDER: S-EPMC4824064 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature