Atlas of Cryptic Genetic Relatedness Among 1000 Human Genomes.

ABSTRACT: A novel computational method for detecting identical-by-descent (IBD) chromosomal segments between sequenced genomes is presented. It utilizes the distribution patterns of very rare genetic variants (vrGVs), which have minor allele frequencies <0.2%. Contrary to the existing probabilistic approaches our method is rather deterministic, because it considers a group of very rare events which cannot happen together only by chance. This method has been applied for exhaustive computational search of shared IBD segments among 1,092 sequenced individuals from 14 populations. It demonstrated that clusters of vrGVs are unique and powerful markers of genetic relatedness, that uncover IBD chromosomal segments between and within populations, irrespective of whether divergence was recent or occurred hun

SUBMITTER: Fedorova L 

PROVIDER: S-EPMC4824066 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature