Role of second-trimester genetic sonography after Down syndrome screening.

ABSTRACT:

Objective

To estimate the effectiveness of second-trimester genetic sonography in modifying Down syndrome screening test results.

Methods

The First and Second Trimester Evaluation of Risk (FASTER) aneuploidy screening trial participants were studied from 13 centers where a 15- to 23-week genetic sonogram was performed in the same center. Midtrimester Down syndrome risks were estimated for five screening test policies: first-trimester combined, second-trimester quadruple, and testing sequentially by integrated, stepwise, or contingent protocols. The maternal age-specific risk and the screening test risk were modified using likelihood ratios derived from the ultrasound findings. Separate likelihood ratios were obtained for the presence or absence of at least one major fetal st

SUBMITTER: Aagaard-Tillery KM 

PROVIDER: S-EPMC4824304 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature