The Typhoid Toxin Promotes Host Survival and the Establishment of a Persistent Asymptomatic Infection.

ABSTRACT: Bacterial genotoxins, produced by several Gram-negative bacteria, induce DNA damage in the target cells. While the responses induced in the host cells have been extensively studied in vitro, the role of these effectors during the course of infection remains poorly characterized. To address this issue, we assessed the effects of the Salmonella enterica genotoxin, known as typhoid toxin, in in vivo models of murine infection. Immunocompetent mice were infected with isogenic S. enterica, serovar Typhimurium (S. Typhimurium) strains, encoding either a functional or an inactive typhoid toxin. The presence of the genotoxic subunit was detected 10 days post-infection in the liver of infected mice. Unexpectedly, its expression promoted the survival of the host, and was associated with a significan

SUBMITTER: Del Bel Belluz L 

PROVIDER: S-EPMC4824513 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature