Effects of Nicotine Patch vs Varenicline vs Combination Nicotine Replacement Therapy on Smoking Cessation at 26 Weeks: A Randomized Clinical Trial.

ABSTRACT:

Importance

Smoking cessation medications are routinely used in health care; it is vital to identify medications that most effectively treat this leading cause of preventable mortality.

Objective

To compare the efficacies of varenicline, combination nicotine replacement therapy (C-NRT), and the nicotine patch for 26-week quit rates.

Design, setting, and participants

Three-group randomized intention-to-treat clinical trial occurring from May 2012 to November 2015 among smokers recruited in the Madison, Wisconsin, and Milwaukee, Wisconsin, communities; 65.5% of smokers offered the study (2687/4102) refused participation prior to randomization.

Interventions

Participants were randomized to one of three 12-week open-label smoking cessation pharmacotherapy groups: (1

SUBMITTER: Baker TB 

PROVIDER: S-EPMC4824537 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature