A large-scale analysis of autophagy-related gene expression identifies new regulators of autophagy.

ABSTRACT: Autophagy is a pathway mediating vacuolar degradation and recycling of proteins and organelles, which plays crucial roles in cellular physiology. To ensure its proper cytoprotective function, the induction and amplitude of autophagy are tightly regulated, and defects in its regulation are associated with various diseases. Transcriptional control of autophagy is a critical aspect of autophagy regulation, which remains largely unexplored. In particular, very few transcription factors involved in the activation or repression of autophagy-related gene expression have been characterized. To identify such regulators, we analyzed the expression of representative ATG genes in a large collection of DNA-binding mutant deletion strains in growing conditions as well as after nitrogen or glucose starva

SUBMITTER: Bernard A 

PROVIDER: S-EPMC4824583 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature