Abundant copy-number loss of CYCLOPS and STOP genes in gastric adenocarcinoma.

ABSTRACT:

Background

Gastric cancer, a leading cause of cancer death worldwide, has been little studied compared with other cancers that impose similar health burdens. Our goal is to assess genomic copy-number loss and the possible functional consequences and therapeutic implications thereof across a large series of gastric adenocarcinomas.

Methods

We used high-density single-nucleotide polymorphism microarrays to determine patterns of copy-number loss and allelic imbalance in 74 gastric adenocarcinomas. We investigated whether suppressor of tumorigenesis and/or proliferation (STOP) genes are associated with genomic copy-number loss. We also analyzed the extent to which copy-number loss affects Copy-number alterations Yielding Cancer Liabilities Owing to Partial losS (CYCLOPS) genes-g

SUBMITTER: Cutcutache I 

PROVIDER: S-EPMC4824836 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature