Applicability and safety of dual-frequency ultrasonic treatment for the transdermal delivery of drugs.

ABSTRACT: Low-frequency ultrasound presents an attractive method for transdermal drug delivery. The controlled, yet non-specific nature of enhancement broadens the range of therapeutics that can be delivered, while minimizing necessary reformulation efforts for differing compounds. Long and inconsistent treatment times, however, have partially limited the attractiveness of this method. Building on recent advances made in this area, the simultaneous use of low- and high-frequency ultrasound is explored in a physiologically relevant experimental setup to enable the translation of this treatment to testing in vivo. Dual-frequency ultrasound, utilizing 20kHz and 1MHz wavelengths simultaneously, was found to significantly enhance the size of localized transport regions (LTRs) in both in vitro and in vivo

SUBMITTER: Schoellhammer CM 

PROVIDER: S-EPMC4825056 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature