Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy.

ABSTRACT:

Background

New treatment options are needed to maintain and improve therapy for tuberculosis, which caused the death of 1.5 million people in 2013 despite potential for an 86 % treatment success rate. A greater understanding of Mycobacterium tuberculosis (M.tb) bacilli that persist through drug therapy will aid drug development programs. Predictive biomarkers for treatment efficacy are also a research priority.

Methods and results

Genome-wide transcriptional profiling was used to map the mRNA signatures of M.tb from the sputa of 15 patients before and 3, 7 and 14 days after the start of standard regimen drug treatment. The mRNA profiles of bacilli through the first 2 weeks of therapy reflected drug activity at 3 days with transcriptional signatures at days 7 and 14 consisten

SUBMITTER: Honeyborne I 

PROVIDER: S-EPMC4825072 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature