Injectable Self-Healing Glucose-Responsive Hydrogels with pH-Regulated Mechanical Properties.

ABSTRACT: Dynamically restructuring pH-responsive hydrogels are synthesized, employing dynamic covalent chemistry between phenylboronic acid and cis-diol modified poly(ethylene glycol) macromonomers. These gels display shear-thinning behavior, followed by a rapid structural recovery (self-healing). Size-dependent in vitro controlled and glucose-responsive release of proteins from the hydrogel network, as well as the biocompatibility of the gels, are evaluated both in vitro and in vivo.

SUBMITTER: Yesilyurt V 

PROVIDER: S-EPMC4825176 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature