An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors.

ABSTRACT: Current anticancer chemotherapy relies on a limited set of in vitro or indirect prognostic markers of tumor response to available drugs. A more accurate analysis of drug sensitivity would involve studying tumor response in vivo. To this end, we have developed an implantable device that can perform drug sensitivity testing of several anticancer agents simultaneously inside the living tumor. The device contained reservoirs that released microdoses of single agents or drug combinations into spatially distinct regions of the tumor. The local drug concentrations were chosen to be representative of concentrations achieved during systemic treatment. Local efficacy and drug concentration profiles were evaluated for each drug or drug combination on the device, and the local efficacy was confirmed t

SUBMITTER: Jonas O 

PROVIDER: S-EPMC4825177 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature