The coaction of tonic and phasic dopamine dynamics.

ABSTRACT: Tonic neurochemical dopamine activity underlies many brain functions; however a consensus on this important concentration has not yet been reached. In this work, we introduce in vivo fast-scan controlled-adsorption voltammetry to report tonic dopamine concentrations (90 ± 9 nM) and the dopamine diffusion coefficient (1.05 ± 0.09 × 10(-6) cm(2) s(-1)) in the mouse brain.

SUBMITTER: Atcherley CW 

PROVIDER: S-EPMC4825181 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature