Mineral content of the maternal diet influences ectopic mineralization in offspring of Abcc6(-/-) mice.

ABSTRACT: Ectopic mineralization disorders inflicting the connective tissues display a spectrum of severity, some developing in utero and being diagnosed by prenatal ultrasound. This study was designed to test the hypothesis that the mineral content of maternal diet can influence the mineralization in the offspring. Pregnant Abcc6(-/-) mice, on 2 different strain backgrounds, were maintained either on normal rodent diet or on "acceleration diet," rich in phosphate and low in magnesium, which has been previously shown to enhance the mineralization processes. The offspring were examined for mineralization by histopathology of various tissues and quantitated by chemical assay of calcium. The ectopic mineralization in the dermal sheath of vibrissae, a progressive biomarker of the overall mineralization,

SUBMITTER: Li Q 

PROVIDER: S-EPMC4825565 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature