Detecting and Quantifying Changing Selection Intensities from Time-Sampled Polymorphism Data.

ABSTRACT: During his well-known debate with Fisher regarding the phenotypic dataset of Panaxia dominula, Wright suggested fluctuating selection as a potential explanation for the observed change in allele frequencies. This model has since been invoked in a number of analyses, with the focus of discussion centering mainly on random or oscillatory fluctuations of selection intensities. Here, we present a novel method to consider nonrandom changes in selection intensities using Wright-Fisher approximate Bayesian (ABC)-based approaches, in order to detect and evaluate a change in selection strength from time-sampled data. This novel method jointly estimates the position of a change point as well as the strength of both corresponding selection coefficients (and dominance for diploid cases) from the allel

SUBMITTER: Shim H 

PROVIDER: S-EPMC4825659 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature