Genetically Determined Variation in Lysis Time Variance in the Bacteriophage φX174.

ABSTRACT: Researchers in evolutionary genetics recently have recognized an exciting opportunity in decomposing beneficial mutations into their proximal, mechanistic determinants. The application of methods and concepts from molecular biology and life history theory to studies of lytic bacteriophages (phages) has allowed them to understand how natural selection sees mutations influencing life history. This work motivated the research presented here, in which we explored whether, under consistent experimental conditions, small differences in the genome of bacteriophage φX174 could lead to altered life history phenotypes among a panel of eight genetically distinct clones. We assessed the clones' phenotypes by applying a novel statistical framework to the results of a serially sampled parallel infection

SUBMITTER: Baker CW 

PROVIDER: S-EPMC4825663 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature