Olfactory impairment predicts cognitive decline in early Parkinson's disease.

ABSTRACT:

Objective

To evaluate the association between baseline olfaction and both cross-sectional and longitudinal cognitive assessments, motor symptoms, non-motor symptoms (NMS), and CSF biomarkers in early Parkinson's disease (PD).

Methods

Parkinson's Progression Marker's Initiative (PPMI) participants underwent baseline olfactory testing with the University of Pennsylvania Smell Identification Test (UPSIT). Serial assessments included measures of motor symptoms, NMS, neuropsychological assessment, and CSF biomarkers. Up to three years follow-up data were included.

Results

At baseline, worse olfaction (lowest tertile) was associated with more severe NMS, including anxiety and autonomic symptoms. Those in the lowest olfactory tertile were more likely to report cognitive impa

SUBMITTER: Fullard ME 

PROVIDER: S-EPMC4825674 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature