Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice.

ABSTRACT: The transplantation of glucose-responsive, insulin-producing cells offers the potential for restoring glycemic control in individuals with diabetes. Pancreas transplantation and the infusion of cadaveric islets are currently implemented clinically, but these approaches are limited by the adverse effects of immunosuppressive therapy over the lifetime of the recipient and the limited supply of donor tissue. The latter concern may be addressed by recently described glucose-responsive mature beta cells that are derived from human embryonic stem cells (referred to as SC-β cells), which may represent an unlimited source of human cells for pancreas replacement therapy. Strategies to address the immunosuppression concerns include immunoisolation of insulin-producing cells with porous biomaterials

SUBMITTER: Vegas AJ 

PROVIDER: S-EPMC4825868 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature